Il15ra^tm1Nsl
Targeted Allele Detail

Summary

• Symbol: Il15ra^tm1Nsl
• Name: interleukin 15 receptor, alpha chain; targeted mutation 1, Nan-Shih Liao
• MGI ID: MGI:2176071
• Synonyms: IL-15Ralpha-
• Gene: Il15ra Location: Chr2:11709992-11738796 bp, + strand Genetic Position: Chr2, 8.97 cM
• Alliance: Il15ra^tm1Nsl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73738
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed PGK-neomycin resistance cassette replaced 1.3 kb of sequence containing exon1, which includes the translation start codon and sequences encoding the signal peptide. (J:73738)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il15ra Mutation: 39 strains or lines available

References

• Original: J:73738 Wu TS, et al., Reduced expression of Bcl-2 in CD8+ T cells deficient in the IL-15 receptor alpha-chain. J Immunol. 2002 Jan 15;168(2):705-12
• All: 1 reference(s)