About   Help   FAQ
Targeted Allele Detail
Symbol: Casp4tm1Yuan
Name: caspase 4, apoptosis-related cysteine peptidase; targeted mutation 1, Junying Yuan
MGI ID: MGI:2159366
Synonyms: casp-11, Casp11-, Caspase-11-
Gene: Casp4  Location: Chr9:5308828-5336783 bp, + strand  Genetic Position: Chr9, 2.46 cM, cytoband A1
Alliance: Casp4tm1Yuan page
Germline Transmission:  Earliest citation of germline transmission: J:46167
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a 1.5 kb genomic fragment containing sequences encoding 16 amino acids of the active site. Western blot analysis on lysates derived from spleen of both LPS-injected and control homozygous mice confirmed that no detectable protein is expressed from this allele. (J:46167)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Casp4 Mutation:  25 strains or lines available
Original:  J:46167 Wang S, et al., Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell. 1998 Feb 20;92(4):501-9
All:  58 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory