Sema3a^tm1.3Tyag
Targeted Allele Detail

Summary

• Symbol: Sema3a^tm1.3Tyag
• Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; targeted mutation 1.3, Takeshi Yagi
• MGI ID: MGI:2158946
• Synonyms: semaphorin III/D knocked-in lacZ
• Gene: Sema3a Location: Chr5:13175381-13652533 bp, + strand Genetic Position: Chr5, 4.31 cM
• Alliance: Sema3a^tm1.3Tyag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43443
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele was generated from Sema3a^tm1Tyag by transient Cre expression in TT-2 cells. Recombination produced three alleles, Sema3a^tm1.1Tyag, Sema3a^tm1.2Tyag and Sema3a^tm1.3Tyag. The Sema3a^tm1.3Tyag allele has the first exon deleted and replaced by a lacZ-neo construct flanked by loxP sites. (J:43443)
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:

43 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sema3a Mutation: 47 strains or lines available

References

• Original: J:43443 Taniguchi M, et al., Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Neuron. 1997 Sep;19(3):519-30
• All: 5 reference(s)