Ptz1a^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Ptz1a^DBA/2J
• Name: pentylenetetrazol induced seizure susceptibility 1a; DBA/2J
• MGI ID: MGI:2158377
• QTL: Ptz1a Location: unknown Genetic Position: Chr2, cM position of peak correlated region/allele: 34.9 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:60775

235 (C57BL/6J x DBA/2J)F2 animals and 26 BXD recombinant inbred strains were analyzed for microsatellite markers on the X chromosome to identify loci associated with pentylenetetrazol (PTZ) induced seizures. Parental strain C57BL/6J exhibits resistance to PTZ induced seizures whereas DBA/2J exhibits susceptibility. Two significant loci mapped to mouse Chromosome 2, Ptz1a and Ptz1b. Ptz1a spans 28 cM - 50 cM with a peak LOD score of 7.9 near D2Mit61 at approximately 34 cM. Cacnb4 maps near Ptz1a and may be a candidate gene. Ptz1b spans 10 cM - 26 cM with a peak LOD score of 3.2 near D2Mit521 at approximately 15 cM. Cacnb2 maps near Pzt1b and may be a candidate gene. Sequence comparison of regions encompassing Cacnb2 and Cacnb4 did not reveal differences between C57BL/6J and DBA/2J. A suggestive locus was detected on mouse Chromosome 7 which the authors name Ptz2.

References

• Original: J:60775 Wakana S, et al., Gene mapping of SEZ group genes and determination of pentylenetetrazol susceptible quantitative trait loci in the mouse chromosome. Brain Res. 2000 Feb 28;857(1-2):286-90
• All: 1 reference(s)