Insq4^SM/J
QTL Variant Detail

Summary

• QTL variant: Insq4^SM/J
• Name: insulin QTL 4; SM/J
• MGI ID: MGI:2157898
• QTL: Insq4 Location: Chr10:103909085-103909229 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 54.72 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased insulin levels in female animals compared to A/J. (J:64138)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome 10, candidate genes for diabesity QTL Igfp3q2 (46 cM) are Aes (43 cM) and Hsp90b1 (49 cM). Aes shows differential expression between A/a and A/A^vy animals on both the restricted and unrestricted diets while Hsp90b1 shows differential expression between the restricted and unrestricted diets on the A/A^vy background. At another locus, Mdm2 (66 cM) is a candidate gene for diabesity QTL Insq4 (59 cM). Mdm2 shows differential expression between the restricted and unrestricted diets on the A/a background.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:64138

The SMXA (SM/J x A/J) RI line was informative in mapping suggestive QTLs for Body Weight, Insulin, Triglyceride and Phospholipid in selected RI Strains. In female mice a QTL (Insq4) influencing Insulin levels in blood mapped to mouse Chromosome 10 and was associated with D10Mit70.

References

• Original: J:64138 Anunciado RV, et al., Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis. Exp Anim. 2000 Jul;49(3):217-24
• All: 1 reference(s)