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QTL Variant Detail
QTL variant: Uvbi2C57BL/6NCr
Name: UVB induced immunosuppression 2; C57BL/6NCr
MGI ID: MGI:2157867
QTL: Uvbi2  Location: Chr17:45622406-45622654 bp  Genetic Position: Chr17, cM position of peak correlated region/allele: 22.26 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C57BL/6NCr
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


Genome wide scan was performed on 100 BALB/cAnNCr x (BALB/cAnNCr x C57BL/6NCr)F1 backcross animals to map QTLs associated with UVB radiation-induced immunosuppression. Parental strains BALB/cAnNCr exhibits low susceptibility to immunosuppression whereas parental strain C57BL/6NCr exhibits high susceptibility to immunosuppression. Two significant QTLs, Uvbi1 and Uvbi2, were mapped to mouse Chromosome 10 at approximately 29 cM (P<0.05 at D10Mit70) and mouse Chromosome 17 at approximately 23.2 cM (P = 0.1 at D17Mit49). Uvbi1 is associated with decreased susceptibility to UVB radiation-induced immunosuppression while Uvbi2 is associated with increased susceptibility to UVB radiation-induced immunosuppression. Uvbi1 maps near Gp49b, the gene for a membrane glycoprotein which inhibits mast cell signaling and may be a candidate gene. Uvbi2 maps distal to the MHC complex.

Original:  J:68418 Clemens KE, et al., Genetic control of susceptibility to UV-induced immunosuppression by interacting quantitative trait loci. Genes Immun. 2000;1(4):251-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.23
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