Etohcta8^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Etohcta8^DBA/2J
• Name: ethanol conditioned taste aversion 8; DBA/2J
• MGI ID: MGI:2157423
• QTL: Etohcta8 Location: Chr9:89859058-89859205 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 47.35 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50271

841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta8 (P<0.01 at D9Mit10) mapped to Chromosome 9 at 49 cM. Etohcta8 is associated with ethanol-induced taste aversion at low-dose ethanol injection following the paired taste. A potential candidate gene mapping near Etohcta8 is the serotonin receptor, Htr1b.

References

• Original: J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
• All: 1 reference(s)