Sluc12^B10.O20/Dem
QTL Variant Detail

Summary

• QTL variant: Sluc12^B10.O20/Dem
• Name: susceptibility to lung cancer 12; B10.O20/Dem
• MGI ID: MGI:2157415
• QTL: Sluc12 Location: Chr12:113860337-113860525 bp Genetic Position: Chr12, cM position of peak correlated region/allele: 62.22 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: B10.O20/Dem

Variant description

• Allele Type: QTL
• Inheritance: Other (see notes)

Notes

Sluc12 is observed to participate in additive interactions with other Sluc loci.

Animals homozygous for B10.O20/Dem-derived alleles at Sluc12 and homozygous for O20/A-derived alleles at Sluc22 exhibit decreased lung tumor size.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50525

The fact that inbred O/20 was more susceptible to lung tumors then Congenic B10.O20 allowed for the mapping of lung tumor genes in OcB Recombinated Congenic strains. Lung tumor size and number could also be assesed by the QTL analysis of F2 mice derived from progenitor O/20 and various OcB strains. Analysis of F2 mice between O/20 and OcB-6 indicated a lung cancer susceptibility gene Sluc12 associated with mouse Chromosome 12 marker D12Nds2.

References

• Original: J:50525 Fijneman RJ, et al., High frequency of interactions between lung cancer susceptibility genes in the mouse: mapping of Sluc5 to Sluc14. Cancer Res. 1998 Nov 1;58(21):4794-8
• All: 2 reference(s)