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QTL Variant Detail
QTL variant: Pvcan3C57BL/6ByJ
Name: protection against vaginal candidiasis 3; C57BL/6ByJ
MGI ID: MGI:2157366
QTL: Pvcan3  Location: Chr18:33199640-33199776 bp  Genetic Position: Chr18, cM position of peak correlated region/allele: 18.17 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C57BL/6ByJ
Allele Type:    QTL
Inheritance:    Not Specified

Mapping and Phenotype information for this QTL, its variants and associated markers


Forty (BALB/cByJ x C57BL/6ByJ)F1 x C57BL/6ByJ backcross animals were typed for 51 microsatellite markers to detect loci associated with protection against vaginal candidiasis. Parental inbred strain BALB/cByJ is protected from candidiasis after immunization and subsequent challenge with Candida albicans where as parental inbred strain C57BL/6ByJ is not protected. The trait appears to be dominantly inherited since (BALB/cByJ x C57BL/6ByJ)F1 animals exhibit protection similar to BALB/cByJ. QTLs were detected on mouse Chromosomes 8, 9, and 18. Pvcan1 maps to mouse Chromosome 8 with a LOD = 2.2 at D8Mit155 and D8Mit58 at approximately 1 cM - 2 cM. A candidate locus for Pvcan1 is the Fc receptor for IgE, Fcer2a. Pvcan2 maps to mouse Chromosome 9 with a LOD = 1.9 at D9Mit67 at approximately 17 cM. A candidate locus for Pvcan2 is Icam1. Pvcan3 maps to mouse Chromosome 18 with a LOD = 2.0 at D18Mit63 at approximately 16 cM. A candidate locus for Pvcan3 is Icam1-rs1.

Original:  J:57639 Mulero-Marchese RD, et al., Strain-dependent migration of lymphocytes to the vaginal mucosa after peripheral immunization. Immunogenetics. 1999 Oct;49(11-12):973-80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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