Apobec1^tm1Chan
Targeted Allele Detail

Summary

• Symbol: Apobec1^tm1Chan
• Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; targeted mutation 1, Lawrence Chan
• MGI ID: MGI:2157210
• Synonyms: apobec-1 -
• Gene: Apobec1 Location: Chr6:122554751-122579403 bp, - strand Genetic Position: Chr6, 57.68 cM
• Alliance: Apobec1^tm1Chan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36051
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Part of intron 6 and exon 7 was replaced with a neomycin selection cassette. (J:36051)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apobec1 Mutation: 27 strains or lines available

References

• Original: J:36051 Nakamuta M, et al., Complete phenotypic characterization of apobec-1 knockout mice with a wild-type genetic background and a human apolipoprotein B transgenic background, and restoration of apolipoprotein B mRNA editing by somatic gene transfer of Apobec-1. J Biol Chem. 1996 Oct 18;271(42):25981-8
• All: 9 reference(s)