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Actd4DBA/2J
QTL Variant Detail
Summary
QTL variant: Actd4DBA/2J
Name: activity-distance traveled 4; DBA/2J
MGI ID: MGI:2157191
QTL: Actd4  Location: Chr9:49434563-49434857 bp  Genetic Position: Chr9, cM position of peak correlated region/allele: 26.83 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  DBA/2J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased locomotor activity compared to C57BL/6J. (J:65696)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:65696

A 2-tiered approach was used to identify QTLs associated with basal locomotor activity in rodents, as measured by distance traveled in an open field test during a 20 minute time interval. First, 25 BXD recombinant inbred (RI) strains were typed for 400 polymorphic markers at an average spacing of 4 cM to identify potential QTLs (B = C57BL/6J, D = DBA/2J). Second, potential QTLs were confirmed by screening approximately 500 animals from a (C57BL/6J x DBA/2J)F2 intercross. Parental strain C57BL/6J exhibitsmore activity compared to parental strain DBA/2J. A locus on mouse Chromosome 1, Actd1, was significantly associated with locomotor activity in both the RI strains and (C57BL/6J x DBA/2J)F2 intercross. Actd1 maps to approximately 65 cM (LOD = 10.5) on mouse Chromosome 1 with a QTL range of 40 cM - 90 cM. QTLs on mouse Chromosome 5, Actd2 at 9 cM (P<0.001 at D5Mit72) and Actd3 at 61 cM (P<5 x 0.0001 at D5Mit278), were identified and confirmed, and a QTL on mouse Chromosome 9, Actd4 at 28 cM (P<2 x 0.0001 at D9Mit94), was identified and confirmed. C57BL/6J-derived alleles increase locomotor activity at Actd1, Actd2, and Actd3, while DBA/2J-derived alleles increase locomotor activity at Actd4.

References
Original:  J:65696 Koyner J, et al., Identification and time dependence of quantitative trait loci for basal locomotor activity in the BXD recombinant inbred series and a B6D2 F2 intercross. Behav Genet. 2000 May;30(3):159-70
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory