Map4^{Gt(pGT1.8geo)2Pgr}
Gene trapped Allele Detail

Summary

• Symbol: Map4^{Gt(pGT1.8geo)2Pgr}
• Name: microtubule-associated protein 4; gene trap 2, Peter Gruss
• MGI ID: MGI:2157047
• Synonyms: Map-4^gt
• Gene: Map4 Location: Chr9:109760528-109913023 bp, + strand Genetic Position: Chr9, 59.83 cM
• Alliance: Map4^{Gt(pGT1.8geo)2Pgr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47961
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Insertion of a gene trap construct results in a fusion protein that would retain the first 139 amino acids including the conserved amino terminus. The fusion protein is predicted to lack the last 986 amino acids of the wild-type protein, including the highly conserved proline-rich domain, the microtubule-binding domain, and the highly conserved carboxy terminus. In addition to the predicted fusion transcript, wild-type mRNA was also detected, indicating that splicing around the gene trap occurs. Activity of the lacZ marker was observed in all tissues throughout development and in all cells examined in the adult animal. (J:47961)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Map4 Mutation: 231 strains or lines available

References

• Original: J:47961 Voss AK, et al., Compensation for a gene trap mutation in the murine microtubule-associated protein 4 locus by alternative polyadenylation and alternative splicing. Dev Dyn. 1998 Jun;212(2):258-66
• All: 1 reference(s)