Pttg1^tm1Sme
Targeted Allele Detail

Summary

• Symbol: Pttg1^tm1Sme
• Name: pituitary tumor-transforming gene 1; targeted mutation 1, Shlomo Melmed
• MGI ID: MGI:2157014
• Synonyms: PTTG-
• Gene: Pttg1 Location: Chr11:43311077-43317078 bp, - strand Genetic Position: Chr11, 25.68 cM
• Alliance: Pttg1^tm1Sme page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72267
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced part of the first exon including the ATG start codon, exons 2 and 3, and about half of the third intron. Northern analysis of testis using an exon 3 cDNA probe did not detect transcript in homozygous mutant mice. (J:72267)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pttg1 Mutation: 16 strains or lines available

References

• Original: J:72267 Wang Z, et al., Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. Mol Endocrinol. 2001 Nov;15(11):1870-9
• All: 15 reference(s)