Skts1^{M. spretus}
QTL Variant Detail

Summary

• QTL variant: Skts1^{M. spretus}
• Name: skin tumor susceptibility 1; M. spretus
• MGI ID: MGI:2156871
• QTL: Skts1 Location: Chr7:54891386-54891582 bp Genetic Position: Chr7, cM position of peak correlated region/allele: 33.37 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: M. spretus

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers resistance to skin tumorigenesis in female animals and confers skin tumor susceptibility in male animals compared to NIH/Ola. (J:27733)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:27733

Susceptibility to skin papillomas in mice was analyzed in a backcross panel of 326 mice derived from (NIH female x M. spretus male)F1 female mice mated back to NIH male mice. Parental strain M. spretus is resistant to skin papilloma formation compared toparental strain NIH. 133 microsatellite markers were screened. Using MAPMAKER/QTL, significant linkage (Mann-Whitney U test) of Skts1 with D7Mit87 (27.8 cM, lod 6.99) and Skts2 with D7Mit43 (64 cM, lod 5.77) was observed on mouse Chromosome 7. The linkage of Skts2 with D7Mit43 was observed in female mice only. Multiple regression analysis supports the evidence for two loci on mouse Chromosome 7. Potential candidate genes mapping near Skts1 are Igf1r (33 cM) and Fah (42.6 cM). Potential candidate genes mapping near Skts2 are Fgfr2 (63 cM) and Hras1 (72.2 cM).

J:110209

Using a panel of markers from 306 (NIH/Ola x outbred Mus spretus)F1 x NIH/Ola (NSP) backcross animals, to identify skin tumor susceptibility QTL, two linkage peaks were indicated.

The proximal locus, Skts14, mapped to app 14.0Mb on Chromosome 7, peaking at Tgfb1 a very strong candidate gene for influencing cancer risk.

Previous studies [J:27733] demonstrated the existance of a skin tumor susceptibility locus, Skts1, on proximal chromosome 7 that controls papilloma development. The current study using the same cross, confimed this QTL.

References

• Original: J:27733 Nagase H, et al., Distinct genetic loci control development of benign and malignant skin tumours in mice. Nat Genet. 1995 Aug;10(4):424-9
• All: 1 reference(s)