Eae12^SJL/J
QTL Variant Detail

Summary

• QTL variant: Eae12^SJL/J
• Name: experimental allergic encephalomyelitis susceptibility 12; SJL/J
• MGI ID: MGI:2156761
• QTL: Eae12 Location: Chr7:36280015-36280104 bp Genetic Position: Chr7, cM position of peak correlated region/allele: 22.44 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SJL/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased EAE susceptibility compared to B10.S/DvTe. (J:53193)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53193

Analysis of 633 (SJL/J x B10.S/DvTe)F2 mice with induced experimental allergic encephalomyelitis (EAE) indicated the presence of a quantitative locus (QTL) involved with the relapsing/remitting (R/R) form of the disorder. Eae12 showed maximum linkage to D7Mit227 at approximatley 16 cM on mouse Chromosome 7. The authors note that this is proximal to another QTL, Eae4 placed at 26 - 50 cM. Stratification of the data by sex indicated that the effect of Eae12 on susceptibility was greater in females than in males.

References

• Original: J:53193 Butterfield RJ, et al., Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct. J Immunol. 1999 Mar 1;162(5):3096-102
• All: 1 reference(s)