Pax6^3Neu
Chemically induced Allele Detail

Summary

• Symbol: Pax6^3Neu
• Name: paired box 6; 3, Neuherberg
• MGI ID: MGI:2156742
• Synonyms: Enu-65, ENU-65
• Gene: Pax6 Location: Chr2:105499245-105527709 bp, + strand Genetic Position: Chr2, 55.31 cM
• Alliance: Pax6^3Neu page

Mutation origin

• Strain of Origin: (102 x C3H)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Insertion
• Mutation details: The mutation was identified as the insertion of single nucleotide (A) In exon 7 following Nucleotide 598. The frameshift results in normal protein through codon 145 of exon 7 followed by 12 aberrant amino acids and a premature stop codon. The linker region, homeodomain, and P/S/T domains are all deleted in the resulting protein. (J:73625)

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax6 Mutation: 90 strains or lines available

Notes

Genbank Accession ID: Y19195

References

• Original: J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
• All: 5 reference(s)