Tria4^STS/A
QTL Variant Detail

Summary

• QTL variant: Tria4^STS/A
• Name: T cell receptor induced activation 4; STS/A
• MGI ID: MGI:2156740
• QTL: Tria4 Location: unknown Genetic Position: Chr7, cM position of peak correlated region/allele: 50.47 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: STS/A

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers decreased lymphocyte proliferation in response to challenge with a low concentration anti-CD3 mAb compared to BALB/cHeA. (J:56029)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:56029

Lymphocytes of mouse strain BALB/cHeA and STS/A differ in their response to the CD3 antibody. BALB/c lymphocytes are intermediate responders while STS lymphocytes do not respond to this stimulus. The authors used recombinat congenic strains of BALB/c - c-STS/Dem (CcS/Dem) series to examine the genetic basis of proliferative response to anti-CD3. Proliferative response to anti-CD3 was examined in 170 (CcS-9 x CcS-11)F2 hybrids. CcS-9 was a high responder strain while CcS-11 is a low responder strain. Statistical evaluation revealed linkage of rsponse to lower doses (0.375 ug/ml) of CD3 mAbb to the marker D7Mit32 (corrected P = 0.038). This data indicated the presence of a locus Tria4 on the central part of Chromosome 7 on an STS-derived segment of the strain CcS-11. No effect of age or sex was found. Putative candidate genes in this region include Pmv31, Emv23, Tlag1 and Emv32.

References

• Original: J:56029 Havelkova H, et al., T-cell proliferative response is controlled by loci Tria4 and Tria5 on mouse chromosomes 7 and 9. Mamm Genome. 1999 Jul;10(7):670-4
• All: 1 reference(s)