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Mop1C57BL/6J
QTL Variant Detail
Summary
QTL variant: Mop1C57BL/6J
Name: morphine preference 1; C57BL/6J
MGI ID: MGI:2156652
QTL: Mop1  Location: Chr6:132578005-146330736 bp  Genetic Position: Chr6, cM position of peak correlated region/allele: 64.03 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased morphine preference compared to DBA/2J. (J:17972)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes
This allele is consistent with a dominant or additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:17972

Morphine consumption was assessed in 606 F2 mice from a C57BL/6J x DBA/2J intercross. A subset of the 606 progeny were tested for QTL (quantitative trait analysis).

An increase in the preference for morphine consumption, Mop1, was mapped between flanking microsatellite markers D6Mit13 and D6Mit15 on Chromosome 6 with a lod score of 15.0.

The authors suggest that this QTL may be related to Qui a locus for quinine taste aversion which also maps to Chromosome 6.

J:32894

Ninety four backcross progeny of a (C57BL/6J x M. spretus)F1 x C57BL/6J cross were mapped for the following loci: D6Mit86, Pon1 - 1.06 +/- 1.058 - Pon2 - 2.128 +/- 1.486 - D6Mit1. An overall order, incorporating data from the Mouse Genome Database (MGD) was reported as follows: Hc6 - Fdpsl10 - D6Mit86 - Sig - Ica1 - Pon1 - Mop1 - Pon2 - D6Mit1 - Col1a2 - Tac1 - Calcr. These genes were said to cover an approximated 5 cM region of the Chromosome. A note added to the paper proof indicates that Pon3, mapped using the same backcross mice, also localized to mouse Chromosome 6 and no recombination between Pon1 and Pon3 was observed. Mop1 was shown mapping with markers more distal then these reported here( J:17972 Berrettini WH, Nat Genet 1994 May;7(1):54-8 )

References
Original:  J:17972 Berrettini WH, et al., Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains [see comments]. Nat Genet. 1994 May;7(1):54-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory