Ots1^LT/Sv
QTL Variant Detail

Summary

• QTL variant: Ots1^LT/Sv
• Name: ovarian teratoma susceptibility 1; LT/Sv
• MGI ID: MGI:2156627
• QTL: Ots1 Location: Chr6:75424566-104480516 bp Genetic Position: Chr6, cM position of peak correlated region/allele: 44.78 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: LT/Sv

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers ovarian tumor susceptibility compared to C57BL/6J. (J:38481)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:38481

The inbred mouse strain LT/Sv expresses a high incidence of spontaneous ovarian tumors. A genome wide scan using markers that were polymorphic between LT/Sv and C57BL/6J were informative in quantitatively mapping the tumor susceptible phenotype in (LT/Svx C57BL/6J)F2 mice to a region of mouse Chromosome 6. The maximum LOD score (8.4) defining this region is flanked by markers D6Mit188 and D6Mit36.

References

• Original: J:38481 Lee GH, et al., Genetic dissection of susceptibility to murine ovarian teratomas that originate from parthenogenetic oocytes. Cancer Res. 1997 Feb 15;57(4):590-3
• All: 1 reference(s)