Bts2^NON/Shi
QTL Variant Detail

Summary

• QTL variant: Bts2^NON/Shi
• Name: bladder tumor susceptibility 2; NON/Shi
• MGI ID: MGI:2156537
• QTL: Bts2 Location: Chr6:29751221-29751333 bp Genetic Position: Chr6, cM position of peak correlated region/allele: 12.36 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NON/Shi

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers bladder tumor susceptibility compared to C57BL/6JShi. (J:51984)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:51984

248 mice derived from reciprocal (C57BL/6JShi x NON/Shi)F1 backcrossed to C57BL/6JShi were informative in mapping QTLs responsible for induced bladder cancer in mice . C57BL/6JShi mice had a longer survival time then did NON/Shi mice. QTL Bts2 mapped with marker D6Mit159 (LOD 2.21) on mouse Chromosome 6.

References

• Original: J:51984 Higashi S, et al., Host genes affecting survival period of chemically induced bladder cancer in mice. J Cancer Res Clin Oncol. 1998;124(12):670-6
• All: 1 reference(s)