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Cms2C57BL/6J
QTL Variant Detail
Summary
QTL variant: Cms2C57BL/6J
Name: resistance to Coccidioides immitis 2; C57BL/6J
MGI ID: MGI:2156518
QTL: Cms2  Location: Chr6:125326686-125339446 bp  Genetic Position: Chr6, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers susceptibility to Coccidioides immitis infection compared to DBA/2J.
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:55132

DBA/2J mice are more resistant to Coccidioides immitis infection than are C57BL/6J mice allowing for the genetic mapping of genes that determine resistance. The BXD RI line was informative to map genes to mouse Chromosomes 4 and 6. One gene was designated as Cms1 and showed a significant association with mouse Chromosome 4 marker Lv, the other gene Cms2 was associated with Tnfrsf1a on mouse Chromosome 6. Moreover (DBA/2J x C57BL/6J) F1 x C57BL/6J backcross progeny that carried the DBA/2J allele at either Tnfrsf1a or Alad exhibited a higher resistant phenotype than mice that carried the C57BL/6J allele

References
Original:  J:55132 Fierer J, et al., Genes influencing resistance to Coccidioides immitis and the interleukin-10 response map to chromosomes 4 and 6 in mice. Infect Immun. 1999 Jun;67(6):2916-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory