Bhr5^A/J
QTL Variant Detail

Summary

• QTL variant: Bhr5^A/J
• Name: bronchial hyperresponsiveness 5; A/J
• MGI ID: MGI:2156474
• QTL: Bhr5 Location: Chr6:115694477-132578150 bp Genetic Position: Chr6, cM position of peak correlated region/allele: 53.29 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to airway hyperresponsiveness compared to C3H/HeJ. (J:33778)
• Inheritance: Dominant

Notes

Heterozygosity for A/J-derived alleles at both Bhr1 and Bhr5 is sufficient to confer the airway hyperresponsive phenotype.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:33778

Using the progeny from the hyperresponsive A/J mice crossed with the hyporepsonsive C3H/HeJ mice, segregation analyses indicated a major QTL locus, acting additively with a polygenic effect, on Chromosome 6.

Using linkage analysis 196 mice from a (C3H/HeJx A/J)F1 x A/J backcross revealed a QTL, Bhr5, with significant linkage for ACh-induced AHR within the interval spanning markers D6Mit62a and D6Mit13, LOD=3.11.

A/J alleles were associated with significantly greater airway responsiveness than were C3H/HeJ alleles. Candidate genes mapping to this region include the Il5 receptor.

References

• Original: J:33778 Ewart SL, et al., Airway hyperresponsiveness to acetylcholine: segregation analysis and evidence for linkage to murine chromosome 6. Am J Respir Cell Mol Biol. 1996 May;14(5):487-95
• All: 1 reference(s)