Skts4^SENCARA/Pt
QTL Variant Detail

Summary

• QTL variant: Skts4^SENCARA/Pt
• Name: skin tumor susceptibility 4; SENCARA/Pt
• MGI ID: MGI:2156219
• QTL: Skts4 Location: Chr5:89418876-124238239 bp Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: SENCARA/Pt

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to skin tumorigenesis compared to BALB/cAnPt. (J:48305)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:48305

Outbred SENCARA/Pt mice are susceptible to the development of skin papillomas whereas BALB/cAnPt mice are highly resistant. In an attempt to find loci contributing to the susceptibile/resistant phenotype, 81 N2 progeny from a (BALB/cAnPt x SENCARA/Pt)F1 x SENCARA/Pt backcross were analyzed in a genome wide scan using 89 microsatellite markers. Using quantitative trait analysis, Skts4 was mapped to mouse Chromosome 5 in a 21 cM interval between D5Mit259 and D5Mit369 (peak = D5Mit188, LOD of 3.75). Suggestive associations were also found with markers on Chromosomes 9, 11 and 12.

References

• Original: J:48305 Mock BA, et al., Multigenic control of skin tumor susceptibility in SENCARA/Pt mice. Carcinogenesis. 1998 Jun;19(6):1109-15
• All: 1 reference(s)