Lwq11^DBA/2
QTL Variant Detail

Summary

• QTL variant: Lwq11^DBA/2
• Name: liver weight QTL 11; DBA/2
• MGI ID: MGI:2156047
• QTL: Lwq11 Location: unknown Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: DBA/2

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66233

QTL effecting body weight, obesity and muscle weight were found on mouse Chromosomes 1, 4, 5, 7, 11, 12, 13, and 17 and for leptin on 14 and insulin on chromosome 4. The cross used in the genome wide scan included approximately 400 F2 mice from a (DU6i xDBA/2)F1 intercross. DU6i is a strain selected for high body weight. 93 microsatellite markers were analyzed in the genome wide scan.

Locations of the QTLs were provided by the authors and may not be equivalent to the closest microsatellites. Abdominalfat weight QTL 3, body weight QTL 13 and liver weight QTL 2 were mapped to Chromosome 5 to positions 80, 81 and 81 respectively.

10.03.2014 - Curator Note: We had originally associated the abdominal fat weight QTL 3 identified here, mapping to 80cM on mouse Chr 5, as Afw3. Afw3 was originally mapped using a different cross, an outbred cross of DU6 x DUK, in J:49578 in 1998. We consider the current mapping study a separate mapping experiment and have named the QTL identified here as Afw15.

10.06.2015 - Curator Note : Because Lwq2 (liver weight QTL 2) was originally mapped in J:49578 in 1998 using an outbred cross of DU6 x DUK, which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Lwq11.

References

• Original: J:66233 Brockmann GA, et al., Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice. Genome Res. 2000 Dec;10(12):1941-57
• All: 1 reference(s)