Tbc1d1^{Nobq1-NZO/HlBom}
QTL Variant Detail

Summary

• QTL variant: Tbc1d1^{Nobq1-NZO/HlBom}
• Name: TBC1 domain family, member 1; NZO/HlBom
• MGI ID: MGI:2156037
• QTL: Tbc1d1 Location: Chr5:64313648-64508829 bp, + strand Genetic Position: Chr5, 32.8 cM

Variant origin

• Strain of Specimen: NZO/HlBom

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased adiposity and serum insulin levels compared to SJL/NBom. (J:66744)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66744

In NZO mice susceptibility to obesity is due in part to leptin resistance conferred by a variant Lepr allele, however this same alleic form is found in non-obese NZW mice suggesting there may be NZO genes that interact with Lepr to cause obesity. In a genome wide scan NZO x (SJL X NZO) F1 mice were informative in mapping two QTLs to mouse Chromosomes 5 and 19: Nob1 mapped with D5Mit392 whereas Nob2 mapped with D19Mit91.

References

• Original: J:66744 Kluge R, et al., Quantitative trait loci for obesity and insulin resistance (Nob1, Nob2) and their interaction with the leptin receptor allele (LeprA720T/T1044I) in New Zealand obese mice. Diabetologia. 2000 Dec;43(12):1565-72
• All: 1 reference(s)