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Listr1C57BL/6ByJ
QTL Variant Detail
Summary
QTL variant: Listr1C57BL/6ByJ
Name: listeriosis resistance 1; C57BL/6ByJ
MGI ID: MGI:2156007
QTL: Listr1  Location: Chr5:77246081-77246203 bp  Genetic Position: Chr5, cM position of peak correlated region/allele: 41.45 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6ByJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers listeriosis susceptibility.
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68879

116 female (BALB/cByJ x C57BL/6ByJ)F2 animals were used to map QTLs associated with resistance to infection by Listeria monocytogenes. Animals were injected intravenously with 2-5 x 104 CFU of L.monocytogenes and assessed for survival time. Death occurs in animals from BALB/cByJ parental strain within 72 hours of inoculation while animals from parental strain C57BL/6ByJ survive indefinitely. QTLs for listeriosis resistance, Listr1 and Listr2, mapped to mouse Chromosome 5 from 41 cM - 59 cM (LOD = 6.8 at D5Mit357) and mouse Chromosome 13 (LOD = 9.5 at D13Mit233), respectively. At Listr1, BALB/cByJ-derived alleles appear to increase survival time in (BALB/cByJ x C57BL/6ByJ)F2 animals infected with L.monocytogenes while the C57BL/6ByJ-derived allele increases survival time in a dominant fashion at Listr2. Animals homozygous for resistance alleles at both loci exhibited greatest survival time whereas animals homozygous for susceptibility alleles at both loci exhibited the shortest average survival time.

References
Original:  J:68879 Boyartchuk VL, et al., Multigenic control of Listeria monocytogenes susceptibility in mice. Nat Genet. 2001 Mar;27(3):259-60
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory