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QTL Variant Detail
QTL variant: Elmaz2CBA/J
Name: elevated maze behavior 2; CBA/J
MGI ID: MGI:2155996
QTL: Elmaz2  Location: Chr5:125178229-141700466 bp  Genetic Position: Chr5, cM position of peak correlated region/allele: 77.27 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  CBA/J
Allele Type:    QTL
Mutation:    Undefined
Mutation detailsThis allele confers increased preference for open arm entry and increased number of open arm entries in the elevated maze test compared to CBA/J. (J:70379)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).

Mapping and Phenotype information for this QTL, its variants and associated markers


A (A/J-Tyrc/Tyrc x CBA/J-Pdebrdl/Pdebrdl)F2 intercross was used to map QTLs associated with elevated plus maze behavior. Parental strain A/J-Tyrc/Tyrc is albino with a mutation in the tyrosinase gene and exhibits strong preference for closed arm entry of the maze. Parental strain CBA/J-Pdebrdl/Pdebrdl is mutant for the Pde6b gene and exhibits a weak preference for open arm entry of the maze. Two loci on mouse Chromosome 5, Elmaz1 and Elmaz2, are linked to open arm entry at 52 cM - 63 cM (LOD=1 6.4 between D5Mit20 and D5Mit405) and at 69 cM - 81 cM (LOD = 30.9 between D5Mit138 and D5Mit101), respectively. Pde6b maps to the first Chromosome 5 interval and is a strong candidate gene for Elmaz1. There is also evidence of linkage of closed armmaze entry with the Tyr gene on mouse Chromosome 7 at 44 cM.

Original:  J:70379 Cohen RM, et al., Quantitative trait loci affecting the behavior of A/J and CBA/J intercross mice in the elevated plus maze. Mamm Genome. 2001 Jul;12(7):501-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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