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QTL Variant Detail
QTL variant: Tlsr1RF/J
Name: thymic lymphoma suppressor region 1; RF/J
MGI ID: MGI:2155939
QTL: Tlsr1  Location: Chr4:88601158-94957775 bp  Genetic Position: Chr4, cM position of peak correlated region/allele: 44.8 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  RF/J
Allele Type:    QTL
Inheritance:    Not Specified

Mapping and Phenotype information for this QTL, its variants and associated markers


PCR analysis using microsatellite DNA polymorphic markers was preformed in (C57BL/6J x RF/J)F1 animals. Allelic losses were detected in 21/47 gamma-radiation induced thymic lymphomas. Analysis of markers located on six other chromosomes as well as on the proximal region of mouse Chromosome 4 indicated the existance of a tumor suppressor gene region (Tlsr1) on mouse Chromosome 4 of about 0.6 cM between the makers D4Wsm1 and D4Mit9. Additionally, a more distal tumor suppressor gene region (Tlsr2) was found centered at D4Mit54. From these data the following order of loci was determined on mouse Chromosome 4: D4Mit50, D4Mit17, D4Wsm1, Tlsr1, D4Mit9, D4Mit205, D4Mit12, Tlsr2, D4Mit54, D4Mit13.

Original:  J:31797 Santos J, et al., Allelic losses on chromosome 4 suggest the existence of a candidate tumor suppressor gene region of about 0.6 cM in gamma-radiation-induced mouse primary thymic lymphomas. Oncogene. 1996 Feb 1;12(3):669-76
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
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