Lmb1^C57BL/6Scr
QTL Variant Detail

Summary

• QTL variant: Lmb1^C57BL/6Scr
• Name: lupus in MRL and B6 F2 cross, QTL 1; C57BL/6Scr
• MGI ID: MGI:2155873
• QTL: Lmb1 Location: Chr4:124264957-150676858 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 57.76 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to splenomegaly, lymphadenopathy, and anti-dsDNA antibody production compared to MRL. (J:45708)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

This allele is consistent with a dominant or additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:45708

In a (MRL-Tnfrsf6^lpr x C57BL/6-Tnfrsf6^lpr)F1 cross involving 274 F2 progeny a quantitative trait locus, Lmb1, identifying lymphadenopathy and/or splenomegaly was significantly associated with a region of mouse Chromosome 4 flanked by markers D4Mit12 and D4Mit33. The highest LOD scores were associated with D4Mit12.

References

• Original: J:45708 Vidal S, et al., Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice. J Clin Invest. 1998 Feb 1;101(3):696-702
• All: 2 reference(s)