Skts7^NIH/Ola
QTL Variant Detail

Summary

• QTL variant: Skts7^NIH/Ola
• Name: skin tumor susceptibility 7; NIH/Ola
• MGI ID: MGI:2155770
• QTL: Skts7 Location: Chr4:117071971-117072206 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 53.43 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NIH/Ola

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to skin tumorigenesis compared to M. spretus. (J:59049)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:59049

Susceptibility to skin papillomas in mice was analyzed in a backcross panel of 326 mice derived from (NIH/Ola female x M. spretus male)F1 female mice mated back to NIH/Ola male mice. Using negative binomial regression analysis, significant linkage of Skts7 with D4Mit37 (lod 3.73) was observed on mouse Chromosome 4.

References

• Original: J:59049 Nagase H, et al., A subset of skin tumor modifier loci determines survival time of tumor-bearing mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15032-7
• All: 1 reference(s)