Dnmt3l^tm1Bes
Targeted Allele Detail

Summary

• Symbol: Dnmt3l^tm1Bes
• Name: DNA methyltransferase 3-like; targeted mutation 1, Timothy Bestor
• MGI ID: MGI:2155766
• Synonyms: Dmnt3l^G
• Gene: Dnmt3l Location: Chr10:77878121-77899456 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Dnmt3l^tm1Bes page

Histological abnormalities and decreased germ cell counts in newborn Dnmt3l^tm1Bes/Dnmt3l^tm1Bes mouse testis

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73452
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing four exons was replaced with an in frame beta-galactosidase-neomycin (beta-geo) fusion gene. A fusion protein is expressed under the contol of the endogenous gene promoter. (J:73452)

Expression

In Mice Carrying this Mutation:	19 assay results 10 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dnmt3l Mutation: 48 strains or lines available

References

• Original: J:73452 Bourc'his D, et al., Dnmt3L and the establishment of maternal genomic imprints. Science. 2001 Dec 21;294(5551):2536-9
• All: 20 reference(s)