Chrm4^tm1Jwe
Targeted Allele Detail

Summary

• Symbol: Chrm4^tm1Jwe
• Name: cholinergic receptor, muscarinic 4; targeted mutation 1, Jurgen Wess
• MGI ID: MGI:2155567
• Synonyms: M4 -, M4 KO, M4R^-
• Gene: Chrm4 Location: Chr2:91757594-91759033 bp, + strand Genetic Position: Chr2, 50.63 cM
• Alliance: Chrm4^tm1Jwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57480
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing sequences encoding the region between the second transmembrane loop and the third intracellular loop was replaced by a neomycin resistance cassette. (J:57480)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chrm4 Mutation: 33 strains or lines available

References

• Original: J:57480 Gomeza J, et al., Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice [see comments]. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10483-8
• All: 42 reference(s)