Chrm3^tm1Jwe
Targeted Allele Detail

Summary

• Symbol: Chrm3^tm1Jwe
• Name: cholinergic receptor, muscarinic 3, cardiac; targeted mutation 1, Jurgen Wess
• MGI ID: MGI:2155562
• Synonyms: M3-, M3R-, mAChR3^-
• Gene: Chrm3 Location: Chr13:9925522-10410883 bp, - strand Genetic Position: Chr13, 3.72 cM
• Alliance: Chrm3^tm1Jwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67919
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A 1.6 kb genomic fragment including the translation start site was replaced with a neomycin resistance cassette. (J:67919)

Generation of the Chrm3^tm1Jwe allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chrm3 Mutation: 50 strains or lines available

References

• Original: J:67919 Yamada M, et al., Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature. 2001 Mar 8;410(6825):207-12
• All: 61 reference(s)