Itgb1^tm2Ref
Targeted Allele Detail

Summary

• Symbol: Itgb1^tm2Ref
• Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 2, Reinhard Fassler
• MGI ID: MGI:2154538
• Synonyms: beta1^-, beta1^neo
• Gene: Itgb1 Location: Chr8:129412135-129459681 bp, + strand Genetic Position: Chr8, 76.09 cM, cytoband E2
• Alliance: Itgb1^tm2Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28330
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A promoterless neomycin resistance gene was inserted in-frame to the ATG of the gene. Northern blot analysis demonstrated that no transcript was produced from this allele. (J:28330)

Expression

In Mice Carrying this Mutation:	195 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb1 Mutation: 59 strains or lines available

References

• Original: J:28330 Fassler R, et al., Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev. 1995 Aug 1;9(15):1896-908
• All: 10 reference(s)