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QTL Variant Detail
QTL variant: Sst1C3HeB/FeJ
Name: susceptibility to tuberculosis 1; C3HeB/FeJ
MGI ID: MGI:2154340
QTL: Sst1  Location: Chr1:81652114-87130822 bp  Genetic Position: Chr1, cM position of peak correlated region/allele: 44.07 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C3HeB/FeJ
Allele Type:    QTL
Mutation:    Undefined
    This allele confers tuberculosis susceptibility compared to C57BL/6J. (J:63410)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).

Mapping and Phenotype information for this QTL, its variants and associated markers


A total of 368 (C3HeB/FeJ x C57BL/6J)F2 mice were analyzed for resistance and susceptibility to Mycobacterium tuberculosis. A subset of 46 F2 susceptible mice exhibited linkage of the susceptible phenotype (marker symbol Sst1) with D1Mit46 on mouse Chromosome 1. The strongest evidence for linkage was found with D1Mit49. Further analysis of 367 F2 mice showed Sst1 to be located within a 11 cM interval flanked by D1Mit46 and D1Mit187. Moreover fine genetic mapping using F2 and backcross progeny showed Sst1 to be located within a range flanked by markers D1Mit334 and D1Mit45 which included D1Mit49.

Original:  J:63410 Kramnik I, et al., Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8560-5
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
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