Lore8^C57BL/6Ibg
QTL Variant Detail

Summary

• QTL variant: Lore8^C57BL/6Ibg
• Name: loss of righting induced by ethanol 8; C57BL/6Ibg
• MGI ID: MGI:2154184
• QTL: Lore8 Location: Chr1:152877901-152878015 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 65.18 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6Ibg

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased loss of righting reflex (LORR) in male animals following alcohol administration compared to DBA/2Ibg. (J:66631)
• Inheritance: Other (see notes)

Notes

This allele exhibits an additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66631

319 (C57BL/6IBG X DBA/2IBG)F2 intercross animals were subjected to full genome scan at an average marker spacing of 20 cM to detect loci affecting loss of righting reflex (LORR) following the administration of ethanol. A significant QTL, Lore8 (loss of righting induced by ethanol 8), mapped to mouse Chromosome 1 at approximately 80 cM (LOD = 3.3 at D1Mit500). The C57BL/6IBG-derived allele appears to increase LORR at Lore8 and exhibits an additive mode of inheritance. A suggestive locus mapped to mouse Chromosome 5 at approximately 26 cM (LOD = 2.3 at D5Mit352). The C57BL/6IBG-derived allele appears to decrease LORR at this locus and is male-specific.

References

• Original: J:66631 Radcliffe RA, et al., Mapping of quantitative trait loci for hypnotic sensitivity to ethanol in crosses derived from the C57BL/6 and DBA/2 mouse strains. Alcohol Clin Exp Res. 2000 Sep;24(9):1335-42
• All: 1 reference(s)