Etohcta1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Etohcta1^C57BL/6J
• Name: ethanol conditioned taste aversion 1; C57BL/6J
• MGI ID: MGI:2154083
• QTL: Etohcta1 Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50271

841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta1 (P<0.01) mapped to Chromosome 1 spanning 73 cM - 98.7 cM in linkage with D1Ncvs56 (73 cM) and Adprt1 (98.6 cM). Etohcta1 is associated with ethanol-induced taste aversion at both high and low doses of ethanol injection following the paired taste. QTLs involved in ethanol-related ataxia, hypothermia, and acute withdrawal also map to the distal portion of Chromosome 1.

References

• Original: J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
• All: 1 reference(s)