Immp2l^{Tg(HLA-A/H2-D)2Enge}
Transgenic Allele Detail

Summary

• Symbol: Immp2l^{Tg(HLA-A/H2-D)2Enge}
• Name: IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae); transgene insertion 2, Victor H Engelhard
• MGI ID: MGI:2153986
• Synonyms: AAD mice
• Gene: Immp2l Location: Chr12:41074089-42002371 bp, + strand Genetic Position: Chr12, 18.69 cM, cytoband B3
• Alliance: Immp2l^{Tg(HLA-A/H2-D)2Enge} page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA/Ca)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Transgenic mice express an interspecies hybrid class I MHC gene, AAD, which contains the alpha-1 and alpha-2 domains of the human HLA-A2.1 gene and the alpha-3 transmembrane and cytoplasmic domains of the murine H-2D gene, under the direction of the human HLA-A2.1 promoter. Immunodetection of the HLA-A2.1 recombinant transgene established that expression was at equivalent levels to endogenous murine class I molecules and to similar transgenic strains. Line 2 inserted into the gene at 41759331-41760601 (Build GRCm38/mm10) resulting in a 1270 bp deletion. The deletion results in a functional knock-out. Founder line 2 has a copy number of greater than 5. (J:31937)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Immp2l Mutation: 27 strains or lines available

References

• Original: J:31937 Newberg MH, et al., Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules. J Immunol. 1996 Apr 1;156(7):2473-80
• All: 21 reference(s)