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Alcp4DBA/2J
QTL Variant Detail
Summary
QTL variant: Alcp4DBA/2J
Name: alcohol preference locus 4, female specific; DBA/2J
MGI ID: MGI:2153881
QTL: Alcp4  Location: unknown  Genetic Position: Chr1, Syntenic
Variant
origin
Strain of Specimen:  DBA/2J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele decreases alcohol preference in female animals compared to C57BL/6J. (J:52086)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52086

Backcross progeny from two sets of crosses between (C57BL/6J x DBA/2J)F1 females x C57BL/6J males (N1 = 262 and N2 = 82) and C57BL/6J females x (C57BL/6J x DBA/2J)F1 males (N1= 73 N2 = 78) were analyzed for alcohol consumption. The difference in alcohol consumption between male and female backcross progeny is significant. Therefore sexes were analyzed separately using chi-square analysis to find quantitative trait loci (QTL). P<0.002 was obtained for linkage with D1Mit295 in females.

References
Original:  J:52086 Peirce JL, et al., A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice. Mamm Genome. 1998 Dec;9(12):942-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory