Scx^tm2Eno
Targeted Allele Detail

Summary

• Symbol: Scx^tm2Eno
• Name: scleraxis scleraxis bHLH transcription factor; targeted mutation 2, Eric N Olson
• MGI ID: MGI:2151296
• Synonyms: scleraxis -
• Gene: Scx Location: Chr15:76341652-76343658 bp, + strand Genetic Position: Chr15, 35.92 cM
• Alliance: Scx^tm2Eno page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:55991
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S7/SvEvBrd and C57BL/6 and Swiss

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-hygromycin resistance cassette replaced exon 1 of the wild-type Scx allele in heterozygous ES cells (Gt(ROSA)26Sor^+/- Scx^tm1Eno-+/-). Injection of lacZ-marked Scx^tm1Eno/Scx^tm2Eno ES cells into wild-type blastocysts resulted in chimeric embryos. (J:55991)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scx Mutation: 12 strains or lines available

References

• Original: J:55991 Brown D, et al., Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis. Development. 1999 Oct;126(19):4317-29
• All: 1 reference(s)