Tg(APOE)1Vln
Transgene Detail

Summary

• Symbol: Tg(APOE)1Vln
• Name: transgene insertion 1, Fred Van Leuven
• MGI ID: MGI:2136595
• Synonyms: tae-II, thy1-ApoE4 line 2
• Transgene: Tg(APOE)1Vln Location: unknown
• Alliance: Tg(APOE)1Vln page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOE)1Vln expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOE (348)

  Apoe	(MGI:88057)

• Mutation details: These transgenic mice express the human APOE (epsilon 4 isoform; APOE4) gene under the direction of the mouse Thy1 promoter. The APOE gene product is detected in neural cell bodies of the brain and spinal cord. (J:128837)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

At birth, transgenic mice are viable, normal in size, and do not display any gross physical or behavioral abnormalities. By two months of age, a progressive decrease in muscular strength and weight loss can be noticed. Sensorimotor defects as determined by a variety of behavioral assays are also present. Histological examination reveals atrophy of skeletal muscle tissue, axonal degeneration, and widespread astrogliosis in brain and spinal cord tissue. The microtubule- associated protein tau (Mapt) is found to be hyperphosphorylated.

References

• Original: J:128837 Tesseur I, et al., Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. Am J Pathol. 2000 Mar;156(3):951-64
• All: 6 reference(s)