Tas1r3^sac-d
Allele Detail

Summary

• Symbol: Tas1r3^sac-d
• Name: taste receptor, type 1, member 3; saccharin preference, variant d
• MGI ID: MGI:1934983
• Synonyms: non-taster
• Gene: Tas1r3 Location: Chr4:155943725-155947810 bp, - strand Genetic Position: Chr4, 87.65 cM
• Alliance: Tas1r3^sac-d page

Mutation origin

• Strain of Origin: DBA/2

Mutation description

• Allele Type: Not Applicable
• Mutation: Nucleotide substitutions
• Mutation details: A polymorphism consisting of an amino acid change (I60T) in taster verses non-taster strains is predicted to produce a novel glycosylation site that would interfere with protein dimerization in nontaster strains. (J:69084)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tas1r3 Mutation: 40 strains or lines available

Notes

This allele, present in the DBA/2J strain, determines low preference for saccharin (0.1% solution) over water (J:5474). Strains 129/SvEv, BALB/c, and C3H/HeJ also carry the allele. The allele is selectively expressed in taste receptor cells. The mechanism of preference is predicted to be related to the incentive value of the taste of saccharin rather than to the threshold for detection (J:5474).

Preference for other sweeteners (acesulfame, dulcin, and sucrose) across a panel of 26 inbred strains showed a high correlation with saccharin preference, suggesting the existence of a single receptor for sweetness (J:9874).

References

• Original: J:5474 Fuller JL, Single-locus control of saccharin preference in mice. J Hered. 1974 Jan-Feb;65(1):33-6
• All: 10 reference(s)