Cbfbtm1Spe
Targeted Allele Detail
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Symbol: |
Cbfbtm1Spe |
Name: |
core binding factor beta; targeted mutation 1, Nancy A Speck |
MGI ID: |
MGI:1934195 |
Synonyms: |
Cbfb- |
Gene: |
Cbfb Location: Chr8:105897306-105944621 bp, + strand Genetic Position: Chr8, 53.04 cM
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Alliance: |
Cbfbtm1Spe page
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Germline Transmission: |
Earliest citation of germline transmission:
J:36593
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance gene replaced the 5' end of exon 5. This mutation is predicted to result in a protein that lacks four amino acids of the heterodimerization domain. RT-PCR analysis on RNA derived from embryos demonstrated that transcripts lacking exon 5 were produced from this allele. Western blot analysis on extracts from ES cells and homozygous embryos confirmed that an aberrant protein was made that appeared to lack sequences encoded by exon 5.
(J:36593)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cbfb Mutation: |
36 strains or lines available
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Original: |
J:36593 Wang Q, et al., The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell. 1996 Nov 15;87(4):697-708 |
All: |
8 reference(s) |
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