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Targeted Allele Detail
Symbol: Prltm1Hmn
Name: prolactin; targeted mutation 1, Nelson D Horseman
MGI ID: MGI:1934021
Synonyms: PRL-
Gene: Prl  Location: Chr13:27241553-27249187 bp, + strand  Genetic Position: Chr13, 12.25 cM
Alliance: Prltm1Hmn page
Germline Transmission:  Earliest citation of germline transmission: J:45243
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA PGK neomycin cassette was inserted into exon 4. This sequence encodes the second alpha helix of the protein. RT-PCR analysis confirmed a lack of wild-type transcript in homozygous mutant mice. Western blotting of pituitary gland extracts revealed the presence of a unique immunoreactive ~10-kDa truncated protein product in homozygous mutant mice. Disrupted prolactin synthesis was confirmed by biological assays. (J:45243)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Prltm1Hmn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Prl Mutation:  21 strains or lines available
Original:  J:45243 Horseman ND, et al., Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. EMBO J. 1997 Dec 1;16(23):6926-35
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory