Vim^tm2Cba
Targeted Allele Detail

Summary

• Symbol: Vim^tm2Cba
• Name: vimentin; targeted mutation 2, Charles Babinet
• MGI ID: MGI:1931879
• Synonyms: Vim-, Vim2
• Gene: Vim Location: Chr2:13579122-13587637 bp, + strand Genetic Position: Chr2, 10.04 cM, cytoband A2
• Alliance: Vim^tm2Cba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21588
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 1 of the Vim gene was disrupted by insertion of a neomycin resistance cassette. Northern analysis of homozygous mutant animals did not detect Vim transcript in lung and spleen, but did detect a minor aberrant transcript in heart. Western analysis and immunofluorescence microsopy did not detect VIM protein in tissues of homozygous mutant mice. (J:21588)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vim Mutation: 37 strains or lines available

References

• Original: J:21588 Colucci-Guyon E, et al., Mice lacking vimentin develop and reproduce without an obvious phenotype. Cell. 1994 Nov 18;79(4):679-94
• All: 10 reference(s)