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Tg(MMTV-Notch4)3Rnc
Transgene Detail
Summary
Symbol: Tg(MMTV-Notch4)3Rnc
Name: transgene insertion 3, Robert Callahan
MGI ID: MGI:1930200
Synonyms: FF1 int-3, FVB-3, MMTV-int-3, MMTV LTR-INT3, TgN(MMTVInt3)3Rnc
Transgene: Tg(MMTV-Notch4)3Rnc  Location: unknown  
Alliance: Tg(MMTV-Notch4)3Rnc page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(MMTV-Notch4)3Rnc expresses 1 gene
 
Mutation detailsA 7.5 kb genomic fragment derived from a Czech II mammary tumor was used to generate transgenic mice. The fragment contained MMTV envelope and 3' LTR sequences and a truncated portion of the mouse Notch4 gene. (J:11644)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Tg(MMTV-Notch4)3Rnc
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Six founder mice with similar phenotypes noted. One line established.
References
Original:  J:11644 Jhappan C, et al., Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev. 1992 Mar;6(3):345-55
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
02/20/2024
MGI 6.23
The Jackson Laboratory