Grin1^tm1Blt
Targeted Allele Detail

Summary

• Symbol: Grin1^tm1Blt
• Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1, Horst Bluethmann
• MGI ID: MGI:1928283
• Synonyms: Grin1^D481N, Grin1^tm1Jnck
• Gene: Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
• Alliance: Grin1^tm1Blt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62289
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Point mutations were introduced by homologous recombination which altered the sequence corresponding to codon 481 from aspartic acid to asparagine. A loxP flanked neomycin/thymidine kinase cassette in intron 10 was removed by transient Cre recombinase expression, leaving one loxP site in the intron. (J:62289)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin1 Mutation: 64 strains or lines available

References

• Original: J:62289 Kew JN, et al., Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site. J Neurosci. 2000 Jun 1;20(11):4037-49
• All: 5 reference(s)