Rora^tm1Mba
Targeted Allele Detail

Summary

• Symbol: Rora^tm1Mba
• Name: RAR-related orphan receptor alpha; targeted mutation 1, Michael Becker-Andre
• MGI ID: MGI:1926597
• Synonyms: RORalpha^-
• Gene: Rora Location: Chr9:68561068-69295528 bp, + strand Genetic Position: Chr9, 37.45 cM
• Alliance: Rora^tm1Mba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46854
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A LacZ gene is inserted in-frame into the exon encoding the second zinc finger. Beta-gal activity was detected in the central nervous system, skin, and testis. (J:46854)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rora Mutation: 41 strains or lines available

References

• Original: J:46854 Steinmayr M, et al., staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3960-5
• All: 3 reference(s)