Tg(Erbb2)1Jek
Transgene Detail

Summary

• Symbol: Tg(Erbb2)1Jek
• Name: transgene insertion 1, Jeffrey E Kudlow
• MGI ID: MGI:1891491
• Synonyms: K14-erbB-2
• Transgene: Tg(Erbb2)1Jek Location: unknown
• Alliance: Tg(Erbb2)1Jek page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Erbb2)1Jek expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Erbb2 (24337)

  Erbb2

  (MGI:95410)

• Mutation details: A constitutively activated form (neu) of the rat Erbb2 gene expressed in skin, driven by the human keratin 14 (KRT14) promoter. (J:47225)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

7 founder mice were made (TG4835, TG4836, TG4837, TG4840, TG4839, TG4831, TG4821), however due to lethality, no lines were established. Phenotypic data presented is pooled for the founders (J:47225).

References

• Original: J:47225 Xie W, et al., Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles. Cell Growth Differ. 1998 Apr;9(4):313-25
• All: 2 reference(s)