Tme
Allele Detail

Summary

• Symbol: Tme
• Name: T-associated maternal effect
• MGI ID: MGI:1862035
• Gene: Tme Location: Chr17:12597496-13237006 bp Genetic Position: Chr17, Syntenic
• Alliance: Tme page

Mutation origin

• Strain of Origin: STOCK t^wLub1 x Chr 17

Mutation description

• Allele Type: Not Applicable
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tme Mutation: 0 strains or lines available

Notes

Tme - recombinant

This locus is deleted in the T^hp deletion and in the partial t haplotype, t^wLub2. This haplotype was recovered as a recombinant between the wild-derived t^wLub2 haplotype and a wild-type chromosome 17. Embryos heterozygous for either of these deletions die at a late embryonic stage if the deletion is inherited from the mother but not if it is inherited from the father (J:7679). Tme must be inherited from the mother in order for normal development to proceed through late stages of gestation. How this effect is produced is not understood. The alleles present in wild-type and t chromosomes are presumably identical.

References

• Original: J:7679 Winking H, et al., Characterization of a recombinant mouse T haplotype that expresses a dominant lethal maternal effect. Genetics. 1984 Dec;108(4):1013-20
• All: 3 reference(s)